science.editor
Posts 45
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KEY CONTENT:
The potential of novel 3D matrices in the formation of cephalic skeletal tissues in vitro ( Self-Funded Students Only)
Key aspects of skeletogenesis have been demonstrated to occur in cranial neural crest (CNC) explants in 2D culture via the in vivo differentiation sequence. The mechanisms creating the characteristic 3D structure of the skull in vivo are also relatively well understood. The aim is to use existing knowledge to develop a 3D culture system employing a new scaffold technology supporting the production of normally organised components of the cranial skeleton. This proof of concept opens up the prospect of a wide range of potential applications in which the correct 3D organisation of cells is the key to success ... The project will involve developing a protocol to enable ingress of cultured CNC into the matrix, followed by investigation of the culture conditions necessary to recreate a typical 3D pattern of skeletal differentiation and morphogenesis in vitro.Applications will be welcomed from self-funded candidates holding, or expecting to obtain, a first or upper second-class honours degree with significant content in relevant subjects such as developmental biology, biochemistry, cell biology, molecular biology, chemical biology and biomedical sciences. For further information contact Dr P.N. Hunt.
Dept/School School of Biological and Biomedical Sciences, Durham University
Project Supervisor(s) Dr P N Hunt, Prof S A Przyborski
Original Source: http://www.findaphd.com/search/showproject.asp?projectid=21119&inst=DURM-SBBS&searchtype=i&theorder=2&page=1
edited by science.editor on 6/2/2010
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