science.editor
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School of Biological and Biomedical Sciences, Durham University
Project Supervisor(s): Prof S A Przyborski
Funding Availability: Directly Funded Project (UK Students Only)
KEY CONTENT:
Development of materials to enhance the growth and function of hepatocytes in 3D
The project is part of ongoing work on developing scaffolds for 3D cell culture, where the 3D environment encourages cells to grow in a more in vivo like manner. In particular, this project involves preparing polymeric scaffolds that are designed for the culture of liver cells in 3D. Liver cell cultures are used by the pharmaceutical industry for toxicity testing of new drug candidates; we have shown that 3D cultures produce cells that are more capable of resisting challenge with toxic agents. There are also broader applications of the research in regenerative medicine. The project will involve preparing porous polymer scaffolds, characterising the scaffolds with a variety of techniques then using them in the culture of liver cells.
Original Source: http://www.jobs.ac.uk/job/ABI850/phd-studentship/
edited by science.editor on 7/29/2010
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