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1/24/2012 8:27:18 AM
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topic:
Nanofiber Sol'ns sees promise in scaffolds 4 organ
science.editor
Posts 92
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Cell culture company sees promise in making scaffolds for artificial organs
1.23.12 | Brandon Glenn
Fresh off supplying the scaffold for the world’s second-ever artificial trachea implant, Ohio State University spinoff Nanofiber Solutions is hoping to expand its work with artificial organs.
The Columbus, Ohio-based company’s technology could be used to create scaffolds for a number of other types of hollow organs, such as intestines, blood vessels and kidneys, chief technology officer Jed Johnson said.
The company’s cell culture products use polymer nanofibers to more accurately simulate the 3-D structure of human tissue ....
Full article here: http://www.medcitynews.com/2012/01/cell-culture-company-sees-promise-in-making-scaffolds-for-artificial-organs/
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11/16/2011 5:18:22 PM
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topic:
MIT Tech Review: Pituitary Gland from Scratch
science.editor
Posts 92
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Researchers Create a Pituitary Gland from Scratch
The results could be an initial step toward generating viable, transplantable human organs.
Wednesday, November 9, 2011, By Erica Westly
Last spring, a research team at Japan's RIKEN Center for Developmental Biology created retina-like structures from cultured mouse embryonic stem cells. This week, the same group reports that it's achieved an even more complicated feat—synthesizing a stem-cell-derived pituitary gland.
The pituitary gland is a small organ at the base of the brain that produces many important hormones and is a key part of the body's endocrine system. It's especially crucial during early development, so the ability to simulate its formation in the lab could help researchers better understand how these developmental processes work. Disruptions in the pituitary have also been associated with growth disorders, such as gigantism, and vision problems, including blindness.
The study, published in this week's Nature, moves the medical field even closer to being able to bioengineer complex organs for transplant in humans.
The experiment wouldn't have been possible without a three-dimensional cell culture ...
Full article here: http://www.technologyreview.com/biomedicine/39108/
edited by science.editor on 11/16/2011
edited by science.editor on 11/17/2011
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11/10/2011 3:40:49 PM
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topic:
Perfecta3D Hanging Drop Plates from 3D Biomatrix
3D Biomatrix
Posts 2
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The Perfecta3D(TM) Hanging Drop Plate, available from 3D Biomatrix, is a versatile 3D cell culture plate designed to [quote=]simplify and [quote=]streamline [quote=]spheroid formation, culture, and subsequent testing of the 3D cellular constructs. Perfecta3D Hanging Drop Plates facilitate efficient formation of [quote=]uniform-size spheroids with reduced consumption of media and reagents.
Learn more: http://3dbiomatrix.com/2011/07/01/perfecta3d-hanging-drop-plates-features/
Will your cell types form spheroids? http://3dbiomatrix.com/2011/07/01/perfecta3d-hanging-drop-plates-cell-types/
Find a distributor: http://3dbiomatrix.com/distributors/
Direct ordering from 3dbiomatrix.com also available.
New! Protocols to use the Perfecta3D Hanging Drop Plates with the Biomek FX: http://3dbiomatrix.com/2011/10/17/perfecta3d-hanging-drop-plates-biomek/
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11/10/2011 3:13:53 PM
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topic:
GEN: 3-D Cell Culture Takes Research Deeper
3D Biomatrix
Posts 2
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This article highlighted some important technologies in 3D cell culture. The 384-well plate developed by Prof. Takayama for spheroid formation has been commercialized and is available at 3DBiomatrix.com. Please see our website for more details.
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10/31/2011 10:09:07 AM
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topic:
Sr. Research Biomedical Engineer Opportunity-RTI
jappleman
Posts 2
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RTI International is one of the world’s leading research institutes, dedicated to improving the human condition by turning knowledge into practice. Our staff of more than 2,800 provides research and technical expertise to governments and businesses in more than 40 countries in the areas of health and pharmaceuticals, education and training, surveys and statistics, advanced technology, international development, economic and social policy, energy and the environment, and laboratory and chemistry services.
Please apply via the link below.
www.rti.org/job13657
The Sr. Research Biomedical Engineer will work in RTP, NC across the Discovery and Analytical Sciences (DAS) and Engineering and Technology (ETU) groups within RTI to leverage and expand their existing mutually interactive capabilities, initiatives and existing programs, and to develop and promote new collaborative research opportunities, working broadly at the intersection of biology and engineering.
Identify, propose, acquire and lead multidisciplinary projects of significant technical complexity in the broad area of biomedical engineering, using both DAS((biology and chemistry) and ETU(engineering) resources and personnel.
Support and manage major subtasks of existing projects
Publish and present outcomes from ongoing research projects and develop IP.
Communicate RTI biomedical engineering capabilities to external organizations including funding agency representatives, professional groups, potential collaborators, commercial interests, and other related external organizations.
Focus on research programs likely funded through DoD and NIH, then expand the client base to include blend of funded programs. Ability to develop commercial opportunities is preferred.
Critical success factors include development of proposals in the aforementioned or related programs areas using personnel from DAS and ETU, contributing to success of existing multidisciplinary programs, publication of research outcomes from those projects, and generation of related intellectual property (IP).
Requirements:
PhD in life science or engineering discipline plus 10 years relevant experience.
Background/training in biology, experience in developing and applying solutions to biomedical challenges at the intersection of biology and engineering, expertise in biomedical materials and/or devices.
Specific experience in the use of cellular models and cell culture facilities preferred.
Proven track history of developing research programs and fostering development as well as procuring funding preferred.
Experience in broad technical program areas to include pharmacology and toxicology. Specific program areas of potential applicability include (but are not limited to): development of organotypic cell models; development of predictive preclinical safety or efficacy models and platforms; and development of three dimensional cell culture models and scaffolding.
Track record of leveraging and expanding interactive capabilities as well as initiatives and programs within groups, and developing and promoting new collaborative research opportunities preferred.
Track record of developing of proposals in the aforementioned or related areas contributing to success of multidisciplinary programs, publication of research outcomes from those projects, and generation of related intellectual property (IP).
*To qualify, applicants must be legally authorized to work in the United States and should not require now, or in the future, sponsorship for employment visa status.
Please apply via the lin below.
www.rti.org/job13657
We are proud to be an EEO/AA employer M/F/D/V. Specific information regarding the laws that are designed to protect you against discrimination relating to your legal right to work in the US can be located at the employment portal www.rti.org/jobs.
Important Information:
RTI participates in the US Government E-Verify program, for specific information on this program please visit our employment portal at www.rti.org/jobs.
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10/31/2011 10:08:11 AM
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topic:
Sr. Research Biomedical Engineer Opportunity-RTI
jappleman
Posts 2
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RTI International is one of the world’s leading research institutes, dedicated to improving the human condition by turning knowledge into practice. Our staff of more than 2,800 provides research and technical expertise to governments and businesses in more than 40 countries in the areas of health and pharmaceuticals, education and training, surveys and statistics, advanced technology, international development, economic and social policy, energy and the environment, and laboratory and chemistry services.
Please apply via the lin below.
www.rti.org/job13657
The Sr. Research Biomedical Engineer will work in RTP, NC across the Discovery and Analytical Sciences (DAS) and Engineering and Technology (ETU) groups within RTI to leverage and expand their existing mutually interactive capabilities, initiatives and existing programs, and to develop and promote new collaborative research opportunities, working broadly at the intersection of biology and engineering.
Identify, propose, acquire and lead multidisciplinary projects of significant technical complexity in the broad area of biomedical engineering, using both DAS((biology and chemistry) and ETU(engineering) resources and personnel.
Support and manage major subtasks of existing projects
Publish and present outcomes from ongoing research projects and develop IP.
Communicate RTI biomedical engineering capabilities to external organizations including funding agency representatives, professional groups, potential collaborators, commercial interests, and other related external organizations.
Focus on research programs likely funded through DoD and NIH, then expand the client base to include blend of funded programs. Ability to develop commercial opportunities is preferred.
Critical success factors include development of proposals in the aforementioned or related programs areas using personnel from DAS and ETU, contributing to success of existing multidisciplinary programs, publication of research outcomes from those projects, and generation of related intellectual property (IP).
Requirements:
PhD in life science or engineering discipline plus 10 years relevant experience.
Background/training in biology, experience in developing and applying solutions to biomedical challenges at the intersection of biology and engineering, expertise in biomedical materials and/or devices.
Specific experience in the use of cellular models and cell culture facilities preferred.
Proven track history of developing research programs and fostering development as well as procuring funding preferred.
Experience in broad technical program areas to include pharmacology and toxicology. Specific program areas of potential applicability include (but are not limited to): development of organotypic cell models; development of predictive preclinical safety or efficacy models and platforms; and development of three dimensional cell culture models and scaffolding.
Track record of leveraging and expanding interactive capabilities as well as initiatives and programs within groups, and developing and promoting new collaborative research opportunities preferred.
Track record of developing of proposals in the aforementioned or related areas contributing to success of multidisciplinary programs, publication of research outcomes from those projects, and generation of related intellectual property (IP).
*To qualify, applicants must be legally authorized to work in the United States and should not require now, or in the future, sponsorship for employment visa status.
Please apply via the lin below.
www.rti.org/job13657
We are proud to be an EEO/AA employer M/F/D/V. Specific information regarding the laws that are designed to protect you against discrimination relating to your legal right to work in the US can be located at the employment portal www.rti.org/jobs.
Important Information:
RTI participates in the US Government E-Verify program, for specific information on this program please visit our employment portal at www.rti.org/jobs.
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10/25/2011 12:16:21 PM
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topic:
Clicking together cultural niches
science.editor
Posts 92
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23 October 2011
Click chemistry allows researchers to snap together simple starting materials to form complex structures with relative ease. Now, researchers in the US have used this strategy to make three-dimensional hydrogels that are not only compatible with living cells but can be tuned to create specialist growing environments - culture niches - for studying cell function. The tuning of these models of the extracellular matrix can be carried out with light using photoconjugation and photocleavage reactions.
Cole DeForest and Kristi Anseth of the University of Colorado, Boulder, explain how growing cells in hydrogel matrix cultural niches can allow researchers to investigate how cells receive information from their surroundings. The hydrogel niches produce a well defined and cytocompatible microenvironment in which different stimuli can be introduced in isolation without interference from the myriad environmental cues of living tissue, for instance. Such three-dimensional systems are much more representative of the living environment in which cells find themselves than the conventional two-dimensional approach to studying cell processes.
Full article here: http://www.rsc.org/chemistryworld/News/2011/October/23101101.asp
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10/25/2011 12:04:14 PM
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topic:
Transparent & Molecular Response 3D Cancer Effort
science.editor
Posts 92
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Oct. 7, 2011, 9:00 a.m. EDT
Transparent and Molecular Response Announce Accelerated Collaborative Research Efforts to Develop Novel 3 Dimensional Cell-Culture Systems for Cancer Research
CHIBA, Japan, Oct 07, 2011 (BUSINESS WIRE) -- Transparent Inc. and Molecular Response LLC, with the world's largest primary tumor bank that contains more than 144,000 primary tumor specimens, accelerate collaborative research efforts to develop the next generation of 3 dimensional cell-culture systems for cancer research.
Improved preclinical models are required to advance our understanding of the molecular aberrations that underpin cancer and are critical for developing and deploying targeted therapies to improve patients' lives. Patient-derived primary tumor cell models grown in 3D culture conditions coupled with molecular characterization provides a stronger correlation to clinical outcomes than conventional preclinical anticancer drug testing.
Full text here: http://www.marketwatch.com/story/transparent-and-molecular-response-announce-accelerated-collaborative-research-efforts-to-develop-novel-3-dimensional-cell-culture-systems-for-cancer-research-2011-10-07
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10/25/2011 12:02:38 PM
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topic:
VistaGen Presents CardioSafe 3D(TM) cardiotox assy
science.editor
Posts 92
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Oct. 5, 2011, 9:30 a.m. EDT
VistaGen Therapeutics Presents Highlights of Its Human Stem Cell-Derived "Micro-Heart" Cardiotoxicity Assay at NIH Symposium on Cardiovascular Regenerative Medicine
SOUTH SAN FRANCISCO, CA, Oct 05, 2011 (MARKETWIRE via COMTEX) -- VistaGen Therapeutics, Inc., a biotechnology company applying stem cell technology for drug rescue and cell therapy, announces a poster presentation of its research and development activities leading to validation of its human stem cell-derived "Micro-Heart" cardiotoxicity bioassay system, CardioSafe 3D(TM), at the fourth Symposium on Cardiovascular Regenerative Medicine hosted by the National Institutes of Health's ("NIH") National Heart, Lung and Blood Institute. The poster was presented by Dr. Ralph Snodgrass, VistaGen's President and Chief Scientific Officer, at the NIH symposium held in Bethesda, Maryland on October 4 - 5, 2011.
...
The poster describes work conducted by VistaGen's scientists in collaboration with scientists at ChanTest Corporation in Cleveland, Capsant Neurotechnologies in Southampton (in the UK), and the laboratory of Dr. Gordon Keller at the University Health Network's McEwen Centre for Regenerative Medicine in Toronto. The research described combines optimized stem cell cardiac differentiation protocols, a novel 3-dimensional culture system, and traditional electrophysiological measurements to assess drug-related safety data. The system, called a "Micro-Heart" Cardiotoxicity Assay, was validated by measuring the dose-dependent effects on cardiomyocyte cell viability and electrophysiological responses, as measured by patch clamp and field potential assays, of twelve compounds with known cardiac cytotoxicity or electrophysiology effects.
Full article here: http://www.marketwatch.com/story/vistagen-therapeutics-presents-highlights-of-its-human-stem-cell-derived-micro-heart-cardiotoxicity-assay-at-nih-symposium-on-cardiovascular-regenerative-medicine-2011-10-05
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10/24/2011 9:36:27 AM
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topic:
What is the best scaffold to cultivate cell in 3D?
jb
Posts 1
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Hello!
I'm new in the 3D "community" and I would like to know if there is a review comparing the strenghts and witnesses of the different scaffolds available.
Thank you for the answer
jb
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10/19/2011 2:49:04 PM
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topic:
GEN: 3-D Cell Culture Takes Research Deeper
science.editor
Posts 92
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Feature Articles: Sep 15, 2011 (Vol. 31, No. 16)
K. John Morrow Jr., Ph.D.
In Vivo-Like Environment Paves Way toward Fresh Insights and Whole-Organ Generation
In vitro cell culture has been a powerful model for in vivo biological processes. However, the majority of studies have been conducted using 2-D culture systems in which cells grow as flat monolayers. Two recent symposia—CHI’s “Bioprocessing Summit” and the “BioMethods Boston” conference—discussed a raft of studies on cellular behavior in 3-D platforms, and how this model may offer a more realistic view of how cells behave in their natural environments.
“Deregulated cell movement is a hallmark of pathological events, including pulmonary disease and cancer metastasis,” said Shuichi Takayama, Ph.D., professor of biomedical engineering at the University of Michigan. To investigate this phenomenon, Dr. Takayama and his team developed a high-throughput platform for cell-migration studies.
...
Researchers and companies featured:
Shuichi Takayama, Ph.D., professor of biomedical engineering at the University of Michigan / 3D Biomatrix
Claudia Fischbach-Teschl, Ph.D., assistant professor of biomedical engineering at Cornell University
Basak Uygun, Ph.D., instructor at the Center for Engineering and Medicine at Massachusetts General Hospital
Stephen Badylak, M.D., Ph.D., professor in the department of surgery at the University of Pittsburgh
Thomas Killian, Ph.D., Rice University / Nano3D Biosciences
Full article here: http://www.genengnews.com/gen-articles/3-d-cell-culture-takes-research-deeper/3810/
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10/17/2011 7:15:48 AM
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topic:
UPDATED: 3-D Matrix, Ltd IPO raises $19M in Japan
science.editor
Posts 92
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3-D Matrix Ltd (Tokyo, Japan) raised Y1.5 billion ($19 million) through the sale of 700,000 shares at Y2,100 per share in an IPO underwritten by SMBC Nikko Securities and six other securities firms. The price was at the high end of the proposed Y1,900-Y2,100 range and values the company at Y10.6 billion ($136.7 million). The first day of trading on the JASDAQ Growth Market of the Osaka Securities Exchange is slated for Oct. 24.
3-D Matrix provides its PuraMatrix peptide hydrogel synthetic scaffold for 3D cell culture in drug discovery, cancer biology, stem cell research and bioproduction.
Original source: http://www.biocentury.com/DailyNews/financial/2011-10-17/3-d-matrix-raises-19m-in-ipo
edited by science.editor on 10/19/2011
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10/13/2011 7:24:19 AM
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topic:
3D cell culture in Nikon Small World competition
science.editor
Posts 92
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A beautiful image. Very nice!
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10/4/2011 8:03:58 AM
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topic:
3D cell culture in Nikon Small World competition
Jônatas
Posts 2
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http://www.nikonsmallworld.com/detail/year/2011/43
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9/18/2011 9:19:21 AM
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topic:
3D cell culture movie (You tube)
Jônatas
Posts 2
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Spheroids of MCF-7 cells movie (new!)
link
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9/16/2011 4:43:38 PM
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topic:
GEN: 3-D Cell Culture Takes Research Deeper
science.editor
Posts 92
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Feature Articles: Sep 15, 2011 (Vol. 31, No. 16)
3-D Cell Culture Takes Research Deeper
K. John Morrow Jr., Ph.D.
In Vivo-Like Environment Paves Way toward Fresh Insights and Whole-Organ Generation
In vitro cell culture has been a powerful model for in vivo biological processes. However, the majority of studies have been conducted using 2-D culture systems in which cells grow as flat monolayers. Two recent symposia—CHI’s “Bioprocessing Summit” and the “BioMethods Boston” conference—discussed a raft of studies on cellular behavior in 3-D platforms, and how this model may offer a more realistic view of how cells behave in their natural environments. ...
Companies featured:
3D Biomatrix
Nano3D Biosciences
Full text here: http://www.genengnews.com/gen-articles/3-d-cell-culture-takes-research-deeper/3810/
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9/5/2011 5:33:27 AM
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topic:
New racks for the P3D perfusion chambers by EBERS!
EBERS
Posts 2
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Aiming to give support to the recently released P3D chambers for cell culture on scaffolds under perfusion conditions, EBERS has created new racks which allow the researcher to carry out culture and seeding experiments in a tidy and friendly experimental set-ups.
CULTURE RACK
It allows the researcher to place the chambers in a vertical position as well as to maintain the chambers and the tubing tidy.
MAIN FEATURES
* Fix the chambers in vertical position
* Up to five chambers in parallel
* Stainless-steel made, easy to clean
* Build-up multiple experimental set-ups in a in a tydy way
SEEDING RACK
Tired of obtaining poor inhomogeneous results with static scaffold seeding techniques? Move to the dynamic seeding and improve your results with the new seeding rack specifically designed for the EBERS P3D perfusion chambers.
This rack allows you to easily perfuse high cell content culture media through the pores of the scaffold in alternating directions at very slow flow rates, allowing the cells to get attached to the surface of the scaffold. This technique has been experimentally proved to provide highly homogeneous cell distributions as well as higher efficiencies compared to the manual seeding techniques.
EBERS has designed this rack to be used with the P3D chambers in dynamic seeding experimental set-ups. It allows the user to set up to five parallel seeding circuits with two chambers in each circuit and, just by easyly opening or closing the circuit stopcocks, using the same rack and circuit to culture the cells on the scaffolds after the seeding process.
MAIN FEATURES
* Five independent parallel seeding circuits
* Two P3D chambers in each circuit
* Stainless-steel made, easy to clean
* Build-up multiple experimental set-ups in a in a tydy way
CONTACT US!!!
Would you like to get further information about our racks? Visit our web site or contact us. We will be happy to answer you questions as soon as possible!
edited by EBERS on 9/5/2011
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8/24/2011 10:12:16 PM
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topic:
Biomaterials Reseach Associate II - Cell Culture
shawnliu
Posts 1
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There is a Biomaterials Reseach Associate II (Cell Culture) opportunity avaialble immediately at Kensey Nash Corporation. Kensey Nash Corporation is a medical device company primarily focused on regenerative medicine utilizing its proprietary technology platforms including collagen, synthetic polymer, extracellular matrix (ECM) and adhesive and coating technology. The Company is recognized as a leader for innovative product development and unique technology in the field of resorbable biomaterials. The Company has an extensive range of products, which are sold through strategic partners in multiple medical markets, including, the cardiology, orthopaedic, sports medicine, spine, endovascular and general surgery markets. The Company is based in Exton, Pennsylvania.
Purpose:
Assist the Biomaterials R&D in the development of new materials and products through testing and characterization of biomaterials. Assure that Kensey Nash products are of consistent and high quality by conducting experiments, assisting Manufacturing and Quality Control, and tabulating data in an organized and retrievable fashion.
Principal Duties:
1. Assist Biomaterials R&D staff with developing test methods and conducting experiments. This may involve mammalian cell culture, immunoassays, and molecular biology techniques and other testing techniques (e.g. chemical and biophysical tests).
2. Tabulate data, prepare reports, and make recommendations on experiments and/or tests; write/issue brief experiment summaries.
3. Keep detailed and accurate records of all experimentation according to GLP guidelines.
4. Manage purchasing of supplies and research reagents as well as overseeing research laboratory equipment maintenance, calibration and services to ensure continuous laboratory operations
5. Train other employees on testing and/or products and manufacturing techniques.
6. Develop new test methods with minimal supervision.
7. Possess a common knowledge of biomaterials.
8. Will be able to conduct assisted research into biomaterials and test methods.
9. Assist with process development and validation
10. Assist the Biomaterials Manufacturing and Quality Control teams as needed.
11. Perform other duties as assigned by the Supervisor.
Abilities/Knowledge:
Good written and oral communications skills; basic math, chemistry, and biology skills; an understanding of laboratory principles and theory, computer literate; high attention to detail and good laboratory organization skills.
Education and Experience
Bachelor’s degree (B.S.) in Biological or chemical science or equivalent with 2 to 5 years related experience and/or training in the area of cell biology or similar biological discipline. Hands-on experience in mammalian cell culture, cellular and protein-based method development required. Experience in biomaterial characterization a plus. R&D experience at biotechnology or medical device company preferred.
Working Conditions:
Will work primarily in Cell Culture laboratory, remainder of time may be spent in Analytical/Biomaterials laboratory. Will be required to work with toxic and/or caustic chemicals. Must follow all safety regulations including the wearing of appropriate attire, including but not limited to lab coat, gloves, goggles, mask, and respirator.
Please apply online: http://www.kenseynash.com/careers
or send cover letter and resume to shawn.liu@kenseynash.com
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8/19/2011 11:33:54 AM
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topic:
Staff Scientist, Gibco Cell Culture Frederick, MD
science.editor
Posts 92
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Location: MS - Mississippi
Sector: Industry
Job Hours: Full-Time
Job Role: Cell Biology
Company: Life Technologies
Job reference: 7453BR
Posted Date: Friday, August 05, 2011 4:49:14 PM
Staff Scientist, Gibco Cell Culture Frederick, MD
Position Objective We are seeking a highly motivated Staff Scientist to join the Cell Culture Essentials group. The successful candidate will be part of the R&D group responsible for developing the media formulations and workflow solutions that enable academic, research, and industrial customers to perform groundbreaking science. This position will be responsible for initiating, directing and executing the design and development of proprietary media formulations that i mprove consistency, increase performance and remove animal origin components from cell culture whenever feasible. Media formulations are based on a broad range of cell types (cell lines, primary cells, and stem cells) and customer applications (protein expression, cytogenetics, drug screening, etc.). Develop functional tools and novel technologies for improving workflow processes, including instrumentation, 2D to 3D cell culture environments and small to large scale cell culture platforms for protein/therapeutic production.
Original source here: http://www.newscientistjobs.com/jobs/job/staff-scientist-cell-culture-ms-mississippi-1401226838.htm
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8/18/2011 9:23:10 AM
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topic:
3D Cell Culture Citations
microtissues
Posts 1
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I am wondering what other 3d cell culture citations are out there.
I have posted all known 3D cell culture citations on the 3D Petri Dish on: 3D Petri Dish Citations
Please reply if you are aware of any others.
edited by microtissues on 8/18/2011
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