The effects of matrix stiffness and RhoA on the phenotypic plasticity of smooth muscle cells in a 3-D biosynthetic hydrogel system

(eng)  

Studies using 2-D cultures have shown that the mechanical properties of the extracellular matrix (ECM) influence cell migration, spreading, proliferation, and differentiation; however, cellular mechanosensing in 3-D remains under-explored. To investi...

Periodical:  Biomaterials  2008/03/18

Authors:  Peyton, S. R., Kim, P. D., Ghajar, C. M., Seliktar, D., Putnam, A. J.

Keywords:  bone-formation, collagen, culture, hydroxyapatite ceramics, in-vitro, marrow stromal cells, osteoblast-like cells, osteoblasts, poly(d,l-lactic acid), polymer scaffolds, stem-cells, surface, tissue engineering