Three-dimensional cell-scaffold constructs promote efficient gene transfection: Implications for cell-based gene therapy

(English)  

To date, introduction of gene-modified cells in vivo is still a critical limitation for cell-based gene therapy. In this study, based on tissue engineering techniques, we developed a three-dimensional (3-D) transfection system to be cell-based gene d...

Periodical:  Tissue Engineering

Authors:  Xie, Y. B., Yang, S. T., Kniss, D. A.

Keywords:  *Elastomers, *Polyesters, *Tissue Engineering/instrumentation/methods, Animals, Cell Proliferation, Cell Survival, Cells, Cultured, Chondrocytes/*metabolism, Collagen/metabolism, Extracellular Matrix/*metabolism, Rabbits, RNA, Messenger/*biosynthesis, Stress, Mechanical