Survival advantages of multicellular spheroids vs. monolayers of HepG2 cells in vitro

(English)  

Mammalian cells grow in three-dimensions (3-D) in vivo. Commonly used two-dimensional (2-D) cell Cultures are inadequate to recreate the biological microenvironment of tumor cells. The potentially different outcomes from 2-D and 3-D culture systems m...

Periodical:  Oncology Reports

Authors:  Li, C. L., Tian, T., Nan, K. J., Zhao, N., Guo, Y. H., Cui, J., Wang, J., Zhang, W. G.

Keywords:  Cell proliferation, COLLAGEN, Elastomer, Electrospun fibers, Fibroblast, LAYERED SILICATE NANOCOMPOSITES, MATRIX, Nanocomposite, ORIENTATION, Osteoblast, OSTEOCLAST, POLYMERIZATION, SCAFFOLDS, STATIC MAGNETIC-FIELD, TISSUE